Vessel

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Work Packages

Work Packages

Name Description
WP 1.1 Education and Training Work GroupReport on the kick of meeting. All beneficiaries.  M6-M40 (Start-End Months)
WP 1.2 Virtual Research Training Centerestablished and functioning. Leading beneficiaries: RHA, TP, MG, AM (M2-M40).
WP 1.3 Project Management Tools. On-line application for project management; Network training events organized; Optimise & track visits and secondments; Establish inter-partner transfer of knowledge; Initiate & track career development plans. MG, AM, ED, CB, KA, RHA (M6-M48).
WP 1.4 Career development plans. Initiate & track career development plans. MG, KA, RHA, ED, TP, AM, CB (M6-M48).
WP 2.1 Cross-sectional Issues Group: installed and functioning. All beneficiaries (M3-M44).
WP 2.2 Dissemination & Technology Transfer Working Group: installed and functioning. VA, AM, TP, RHA (M3-M44).
WP 2.3 Data Integrating Tool. On-line system is installed and functioning. RHA, AM, MG, AG, ED (M6-M48).
WP 2.4 Exploitation. Intellectual Property Committee installed and functioning. All beneficiaries (M6-M48).
WP 3.1 Wnt signaling and cross-talk with other signalling pathways. Generation and analysis of mutant mice. Report on roles of Wnt signalling in angiogenesis and BBB. ED, RHA, KA, MG (M1-M36). ESR3
WP 3.2 Angiopoietin signaling. Generation and analysis of mutant mice. Report on role of Tie1 & Ang2 in (lymph) angiogenesis. KA, RHA, MG, CB (M2-M37). ESR5
WP 3.3 Calcineurin/NFAT & vascular connexins. Generation and analysis of mutant mice. Report on role of calcineurin/NFAT and connexions in vascular development. TP, ED, KA, AM (M1-M36). ESR9
WP 3.4 PI3K-dependent phospholipids. Generation and analysis of mutant mice and cells derive thereof. Report on role of lipids PIP2/PIP3 in angiogenesis. MG, RHA, ED, KA, CB (M3-M38). ESR7
WP 3.5 G-protein coupled receptors. Generation and analysis of mutant mice and cells derive thereof. Report on the roles of GPCRs in vascular biology. CB, MG, ED, KA, RHA (M5-M40). ESR11
WP 3.6 Origin and biology of the embryonic haematogenic endothelium. Isolation of endothelial cells from different stages and hematopoietic profiles. Generation and analysis of mutant mice. Report on the genetic profile of the hematogenic endothelium. AM, TP. KA, RHA, ED (M10-M45). ESR2
WP 4.1 Transcriptional networks and cell-cell communication analysed in mutant/knock-down endothelial cells.  Report on the novel putative downstream regulators and pathways in lymphatic vasculature. TP, ED, KA, RHA (M9-M44). ESR10
WP 4.2 Molecular mediators of Wnt signaling in BBB development. Generation and analysis of mutant mice and zebrafish, and cells derived thereof. Report on the putative modulation of BBB by Wnt signalling and detailed protocol on an in vitro assay to test BBB integrity and control of permeability. ED, CB, AG, AM, MG (M12-M36). ESR3/4
WP 4.3 Molecular regulators in the pulmonary vasculature. Transcriptional and proteomic profiles of lung endothelial cells. Report on the putative specific regulators of pulmonary vasculature. RHA, AM, MG, ED, TP, KA (M10-M33). ER1
WP 4.4 Mechanical forces and transcription. Microarray data analysis of blood & lymphatic endothelial cells subjected to shear stress. Report on newly identified transcription profile induced by mechanical forces in BECs and LECs. AM, TP, ED, RHA, CB (M9-M44). ESR1
WP 5.1 Retina angiogenesis: role of pericyte signaling. Generation and analysis of mutant mice and cells derive thereof. Report on role of PI3K/PTEN and NOTCH in perivascular cells. RHA, MG, CB, ED, KA (M13-M36). (secondment?)
WP 5.2 Blood brain barrier (BBB): regulation by pericytes. Generation of pericytes deficient mice and cells derived thereof. Report on novel mechanism of regulation of BBB by pericytes. CB, ED, RHA (M13-M48). ESR12
WP 6.1 Pathological (lymph) angiogenesis. Generation of mutant mice and disease models. Report on the role of signalling pathways in pathological (lymph) angiogenesis. TP, MG, KA, RHA, AM, VA, (M10-M45). ESR8
WP 6.2 Lymphatic dysfunction in adipose tissue development. Analysis of mutant mice on adipose tissue function and inflammation. Report on how lymphatic dysfunction contributes to fat accumulation. KA, TP (M12-M47).
WP 6.3 Pathological alterations of BBB. Generation and analysis of mutant mice and brain injury models. Report on the role of Wnt signalling on BBB recovery after stroke. ED, CB, MG, RHA, TP, KA (M12-M47). ESR4
WP 7.1 2-photon (2P)/ light-sheet fluorescent microscopy. High-resolution large-field Ultramicroscope and 2-photon microscope for imaging fixed tissue and small animals. Report on the advances in large field untramicroscopeand 2-photon high-resolution microscopy. VA, RHA, AM, MGE, TP (M14-M31). ER2
WP 7.2 Optimized fluorescent tags for labeling vascular specific antibodies. Analysis of vascular structure with the antibody-quantum dots conjugates. Report on the characterization of antibody-quantum dotes conjugates. VA, TP, AM, RHA (M10-M27)
WP 7.3 Controlled regulation of vascular networks using functionalized silica nanoparticles. Generation of silica nanoporous particles and in vivo analysis of nanoporous drug delivery in BBB and tumor model. Report on development of silica nonporous as an alternative system to deliver drugs. AG, MG, ED, TP (M30-M37). ER4